Fidelity lost approximately $1 billion in value of its Wyeth (NYSE: WYE) stock holdings on Tuesday, according to an article in today's Boston Globe. The stock tumbled almost a quarter of its value when reports were released that it's hormone-replacement therapy may actually increase health risks for women. SEC records indicate that Fidelity is the largest shareholder in Wyeth with 71 million shares. Fifteen Fidelity funds are invested in the company. 

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